Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC

ADP-heptose activates the protein kinase ALPK1 triggering TIFA phosphorylation at Thr9, the recruitment of TRAF6 and the subsequent production of inflammatory mediators. Here, we demonstrate that ADP-heptose also stimulates the formation of Lys63- and Met1-linked ubiquitin chains to activate the TAK...

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Detalles Bibliográficos
Autores principales: Snelling, Tom, Shpiro, Natalia, Gourlay, Robert, Lamoliatte, Frederic, Cohen, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Signaling
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704527/
https://www.ncbi.nlm.nih.gov/pubmed/36098982
http://dx.doi.org/10.1042/BCJ20220401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704527/
https://www.ncbi.nlm.nih.gov/pubmed/36098982
http://dx.doi.org/10.1042/BCJ20220401

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