Alcohol inhibits the metabolism of dimethyl fumarate to the active metabolite responsible for decreasing relapse frequency in the treatment of multiple sclerosis

Dimethyl fumarate (DMF) is a first-line prodrug for the treatment of relapsing-remitting multiple sclerosis (RRMS) that is completely metabolized to monomethyl fumarate (MMF), the active metabolite, before reaching the systemic circulation. Its metabolism has been proposed to be due to ubiquitous es...

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Detalles Bibliográficos
Autores principales: Yang, Bing, Parker, Robert B., Meibohm, Bernd, Temrikar, Zaid H., Srivastava, Ashish, Laizure, S. Casey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704628/
https://www.ncbi.nlm.nih.gov/pubmed/36441753
http://dx.doi.org/10.1371/journal.pone.0278111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704628/
https://www.ncbi.nlm.nih.gov/pubmed/36441753
http://dx.doi.org/10.1371/journal.pone.0278111

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