Claspin haploinsufficiency leads to defects in fertility, hyperplasia and an increased oncogenic potential

Claspin is an adaptor protein required for ATR-dependent phosphorylation of CHK1 during S-phase following DNA replication stress. Claspin expression is highly variable in cancer, with low levels frequently correlating with poor patient survival. To learn more about the biological consequences of red...

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Detalles Bibliográficos
Autores principales: Madgwick, Suzanne, Luli, Saimir, Sellier, Helene, Butterworth, Jacqueline A., Leslie, Jack, Moore, Adam J., Corbin, Emma K., Yemm, Adrian I., Chiremba, Robson T., Tiniakos, Dina, Oakley, Fiona, Perkins, Neil D., Hunter, Jill E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Cancer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704638/
https://www.ncbi.nlm.nih.gov/pubmed/36240068
http://dx.doi.org/10.1042/BCJ20220101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704638/
https://www.ncbi.nlm.nih.gov/pubmed/36240068
http://dx.doi.org/10.1042/BCJ20220101

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