Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway

Previously, we discovered that deletion of c-Rel in the Eµ-Myc mouse model of lymphoma results in earlier onset of disease, a finding that contrasted with the expected function of this NF-κB subunit in B-cell malignancies. Here we report that Eµ-Myc/cRel(−/−) cells have an unexpected and major defec...

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Detalles Bibliográficos
Autores principales: Hunter, Jill E., Campbell, Amy E., Hannaway, Nicola L., Kerridge, Scott, Luli, Saimir, Butterworth, Jacqueline A., Sellier, Helene, Mukherjee, Reshmi, Dhillon, Nikita, Sudhindar, Praveen D., Shukla, Ruchi, Brownridge, Philip J., Bell, Hayden L., Coxhead, Jonathan, Taylor, Leigh, Leary, Peter, Hasoon, Megan S.R., Collins, Ian, Garrett, Michelle D., Eyers, Claire E., Perkins, Neil D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Cancer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704646/
https://www.ncbi.nlm.nih.gov/pubmed/36240066
http://dx.doi.org/10.1042/BCJ20220102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704646/
https://www.ncbi.nlm.nih.gov/pubmed/36240066
http://dx.doi.org/10.1042/BCJ20220102

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