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De novo sequencing and construction of a unique antibody for the recognition of alternative conformations of cytochrome c in cells

Cytochrome c (cyt c) can undergo reversible conformational changes under biologically relevant conditions. Revealing these alternative cyt c conformers at the cell and tissue level is challenging. A monoclonal antibody (mAb) identifying a key conformational change in cyt c was previously reported, b...

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Detalles Bibliográficos
Autores principales: Tomasina, Florencia, Martínez, Jennyfer, Zeida, Ari, Chiribao, María Laura, Demicheli, Verónica, Correa, Agustín, Quijano, Celia, Castro, Laura, Carnahan, Robert H., Vinson, Paige, Goff, Matt, Cooper, Tracy, McDonald, W. Hayes, Castellana, Natalie, Hannibal, Luciana, Morse, Paul T., Wan, Junmei, Hüttemann, Maik, Jemmerson, Ronald, Piacenza, Lucía, Radi, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704708/
https://www.ncbi.nlm.nih.gov/pubmed/36378644
http://dx.doi.org/10.1073/pnas.2213432119