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Targeting APLN/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models

Type 2 diabetes mellitus is one of the most prevalent metabolic diseases presenting with systemic pathologies, including reproductive disorders in male diabetic patients. However, the molecular mechanisms that contributing to spermatogenesis dysfunction in diabetic patients have not yet been fully e...

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Detalles Bibliográficos
Autores principales: Song, Ke, Yang, Xinyan, An, Geng, Xia, Xinyu, Zhao, Jiexiang, Xu, Xiaoheng, Wan, Cong, Liu, Tianyuan, Zheng, Yi, Ren, Shaofang, Wang, Mei, Chang, Gang, Cronin, Shane J. F., Penninger, Josef M., Jing, Tao, Ou, Xianghong, Rao, Shuan, Liu, Zhaoting, Zhao, Xiao-Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705293/
https://www.ncbi.nlm.nih.gov/pubmed/36443325
http://dx.doi.org/10.1038/s41467-022-34990-3