Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas

Basal-like breast cancers, an aggressive breast cancer subtype that has poor treatment options, are thought to arise from luminal mammary epithelial cells that undergo basal plasticity through poorly understood mechanisms. Using genetic mouse models and ex vivo primary organoid cultures, we show tha...

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Detalles Bibliográficos
Autores principales: Kern, Joseph G., Tilston-Lunel, Andrew M., Federico, Anthony, Ning, Boting, Mueller, Amy, Peppler, Grace B., Stampouloglou, Eleni, Cheng, Nan, Johnson, Randy L., Lenburg, Marc E., Beane, Jennifer E., Monti, Stefano, Varelas, Xaralabos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705439/
https://www.ncbi.nlm.nih.gov/pubmed/36443313
http://dx.doi.org/10.1038/s41467-022-34864-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705439/
https://www.ncbi.nlm.nih.gov/pubmed/36443313
http://dx.doi.org/10.1038/s41467-022-34864-8

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