Hydrophobicity of arginine leads to reentrant liquid-liquid phase separation behaviors of arginine-rich proteins

Intrinsically disordered proteins rich in cationic amino acid groups can undergo Liquid-Liquid Phase Separation (LLPS) in the presence of charge-balancing anionic counterparts. Arginine and Lysine are the two most prevalent cationic amino acids in proteins that undergo LLPS, with arginine-rich prote...

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Detalles Bibliográficos
Autores principales: Hong, Yuri, Najafi, Saeed, Casey, Thomas, Shea, Joan-Emma, Han, Song-I, Hwang, Dong Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705477/
https://www.ncbi.nlm.nih.gov/pubmed/36443315
http://dx.doi.org/10.1038/s41467-022-35001-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705477/
https://www.ncbi.nlm.nih.gov/pubmed/36443315
http://dx.doi.org/10.1038/s41467-022-35001-1

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