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Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism
Transient lysosomal damage after infection with cytosolic pathogens or silica crystals uptake results in protease leakage. Whether limited leakage of lysosomal contents into the cytosol affects the function of cytoplasmic organelles is unknown. Here, we show that sterile and non-sterile lysosomal da...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705561/ https://www.ncbi.nlm.nih.gov/pubmed/36443305 http://dx.doi.org/10.1038/s41467-022-34632-8 |