Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism

Transient lysosomal damage after infection with cytosolic pathogens or silica crystals uptake results in protease leakage. Whether limited leakage of lysosomal contents into the cytosol affects the function of cytoplasmic organelles is unknown. Here, we show that sterile and non-sterile lysosomal da...

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Detalles Bibliográficos
Autores principales: Bussi, Claudio, Heunis, Tiaan, Pellegrino, Enrica, Bernard, Elliott M., Bah, Nourdine, Dos Santos, Mariana Silva, Santucci, Pierre, Aylan, Beren, Rodgers, Angela, Fearns, Antony, Mitschke, Julia, Moore, Christopher, MacRae, James I., Greco, Maria, Reinheckel, Thomas, Trost, Matthias, Gutierrez, Maximiliano G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705561/
https://www.ncbi.nlm.nih.gov/pubmed/36443305
http://dx.doi.org/10.1038/s41467-022-34632-8

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