In Vitro N-Glycan Mannosyl-Phosphorylation of a Therapeutic Enzyme by Using Recombinant Mnn14 Produced from Pichia pastoris

Enzyme replacement therapy for lysosomal storage diseases usually requires recombinant enzymes containing mannose-6-phosphate (M6P) glycans for cellular uptake and lysosomal targeting. For the first time, a strategy is established here for the in vitro mannosyl-phosphorylation of high-mannose type N...

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Detalles Bibliográficos
Autores principales: Kang, Ji-Yeon, Choi, Hong-Yeol, Kim, Dong-Il, Kwon, Ohsuk, Oh, Doo-Byoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Microbiology and Biotechnology 2021
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705852/
https://www.ncbi.nlm.nih.gov/pubmed/33144549
http://dx.doi.org/10.4014/jmb.2010.10033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705852/
https://www.ncbi.nlm.nih.gov/pubmed/33144549
http://dx.doi.org/10.4014/jmb.2010.10033

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