The β-carboline Harmine improves the therapeutic benefit of anti-PD1 in melanoma by increasing the MHC-I-dependent antigen presentation

Harmine is a dual-specificity tyrosine-regulated kinase 1A (DYRK1A) inhibitor that displays a number of biological and pharmacological properties. Also referred to as ACB1801 molecule, we have previously reported that harmine increases the presentation of major histocompatibility complex (MHC)-I-dep...

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Detalles Bibliográficos
Autores principales: Noman, Muhammad Zaeem, Bocci, Irene Adelaide, Karam, Manale, Moer, Kris Van, Bosseler, Manon, Kumar, Akinchan, Berchem, Guy, Auclair, Christian, Janji, Bassam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705972/
https://www.ncbi.nlm.nih.gov/pubmed/36458012
http://dx.doi.org/10.3389/fimmu.2022.980704

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705972/
https://www.ncbi.nlm.nih.gov/pubmed/36458012
http://dx.doi.org/10.3389/fimmu.2022.980704

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