Tacrolimus pharmacokinetics in pediatric nephrotic syndrome: A combination of population pharmacokinetic modelling and machine learning approaches to improve individual prediction

Background and Aim: Tacrolimus (TAC) is a first-line immunosuppressant for the treatment of refractory nephrotic syndrome (RNS), but the pharmacokinetics of TAC varies widely among individuals, and there is still no accurate model to predict the pharmacokinetics of TAC in RNS. Therefore, this study...

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Detalles Bibliográficos
Autores principales: Huang, Qiongbo, Lin, Xiaobin, Wang, Yang, Chen, Xiujuan, Zheng, Wei, Zhong, Xiaoli, Shang, Dewei, Huang, Min, Gao, Xia, Deng, Hui, Li, Jiali, Zeng, Fangling, Mo, Xiaolan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706003/
https://www.ncbi.nlm.nih.gov/pubmed/36457704
http://dx.doi.org/10.3389/fphar.2022.942129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706003/
https://www.ncbi.nlm.nih.gov/pubmed/36457704
http://dx.doi.org/10.3389/fphar.2022.942129

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