Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice

OBJECTIVE: Treatment with glucagon receptor antagonists (GRAs) reduces blood glucose but causes dyslipidemia and accumulation of fat in the liver. We investigated the acute and chronic effects of glucagon on lipid metabolism in mice. METHODS: Chronic effects of glucagon receptor signaling on lipid m...

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Detalles Bibliográficos
Autores principales: Galsgaard, Katrine D., Elmelund, Emilie, Johansen, Christian D., Bomholt, Anna B., Kizilkaya, Hüsün S., Ceutz, Frederik, Hunt, Jenna E., Kissow, Hannelouise, Winther-Sørensen, Marie, Sørensen, Charlotte M., Kruse, Thomas, Lau, Jesper F., Rosenkilde, Mette M., Ørskov, Cathrine, Christoffersen, Christina, Holst, Jens J., Wewer Albrechtsen, Nicolai J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706156/
https://www.ncbi.nlm.nih.gov/pubmed/36400402
http://dx.doi.org/10.1016/j.molmet.2022.101639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706156/
https://www.ncbi.nlm.nih.gov/pubmed/36400402
http://dx.doi.org/10.1016/j.molmet.2022.101639

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