6-Thioguanosine Monophosphate Prodrugs Display Enhanced Performance against Thiopurine-Resistant Leukemia and Breast Cancer Cells

[Image: see text] Thiopurines are in widespread clinical use for the treatment of immunological disorders and certain cancers. However, treatment failure due to resistance or adverse drug reactions are common, asking for new therapeutic strategies. We investigated the potential of 6-thioguanosine mo...

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Detalles Bibliográficos
Autores principales: Moreno, Sarah, Fickl, Magdalena, Bauer, Ingo, Brunner, Melanie, Rázková, Anna, Rieder, Dietmar, Delazer, Isabel, Micura, Ronald, Lusser, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706553/
https://www.ncbi.nlm.nih.gov/pubmed/36374020
http://dx.doi.org/10.1021/acs.jmedchem.2c01010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706553/
https://www.ncbi.nlm.nih.gov/pubmed/36374020
http://dx.doi.org/10.1021/acs.jmedchem.2c01010

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