Cargando…

6-Thioguanosine Monophosphate Prodrugs Display Enhanced Performance against Thiopurine-Resistant Leukemia and Breast Cancer Cells

[Image: see text] Thiopurines are in widespread clinical use for the treatment of immunological disorders and certain cancers. However, treatment failure due to resistance or adverse drug reactions are common, asking for new therapeutic strategies. We investigated the potential of 6-thioguanosine mo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Moreno, Sarah, Fickl, Magdalena, Bauer, Ingo, Brunner, Melanie, Rázková, Anna, Rieder, Dietmar, Delazer, Isabel, Micura, Ronald, Lusser, Alexandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706553/ https://www.ncbi.nlm.nih.gov/pubmed/36374020 http://dx.doi.org/10.1021/acs.jmedchem.2c01010

Ejemplares similares

Synthesis of 4-thiouridines with prodrug functionalization for RNA metabolic labeling
por: Moreno, Sarah, et al.
Publicado: (2022)

Thioguanosine Conversion Enables mRNA‐Lifetime Evaluation by RNA Sequencing Using Double Metabolic Labeling (TUC‐seq DUAL)
por: Gasser, Catherina, et al.
Publicado: (2020)

Converging Fate of the Oxidation and Reduction of 8-Thioguanosine
por: Taras-Goslinska, Katarzyna, et al.
Publicado: (2019)

Thermodynamic and structural contributions of the 6-thioguanosine residue to helical properties of RNA
por: Gładysz, Michał, et al.
Publicado: (2019)

Distinct 5-methylcytosine profiles in poly(A) RNA from mouse embryonic stem cells and brain
por: Amort, Thomas, et al.
Publicado: (2017)

Towards a comprehensive understanding of RNA deamination: synthesis and properties of xanthosine-modified RNA
por: Mair, Stefan, et al.
Publicado: (2022)

Superior cellular activities of azido- over amino-functionalized ligands for engineered preQ(1) riboswitches in E.coli
por: Neuner, Eva, et al.
Publicado: (2018)

Development of New 1,3-Diazaphenoxazine Derivatives (ThioG-Grasp) to Covalently Capture 8-Thioguanosine
por: Fuchi, Yasufumi, et al.
Publicado: (2015)

Synthesis of 4′-Substituted Carbocyclic Uracil Derivatives and Their Monophosphate Prodrugs as Potential Antiviral Agents
por: Biteau, Nicolas G., et al.
Publicado: (2023)

Pharmacogenetics of thiopurine therapy: from thiopurine S-methyltransferase to S-adenosylmethionine
por: Mlinarič-Raščan, Irena, et al.
Publicado: (2009)

Pharmacogenetics of thiopurines
por: Franca, Raffaella, et al.
Publicado: (2019)

Synthesis and Antiviral Activity of a Series of 2′-C-Methyl-4′-thionucleoside Monophosphate Prodrugs
por: Dentmon, Zackery W., et al.
Publicado: (2020)

Thiopurine Methyltransferase Activity and Thiopurine Metabolites in Inflammatory Bowel Disease
por: El-Matary, Wael
Publicado: (2020)

Excited-State Dynamics of the Thiopurine Prodrug 6-Thioguanine: Can N9-Glycosylation Affect Its Phototoxic Activity?
por: Ashwood, Brennan, et al.
Publicado: (2017)

CHD1 controls H3.3 incorporation in adult brain chromatin to maintain metabolic homeostasis and normal lifespan
por: Schoberleitner, Ines, et al.
Publicado: (2021)

Assessment of Thiopurine–based drugs according to Thiopurine S-methyltransferase genotype in patients with Acute Lymphoblastic Leukemia
por: Azimi, F, et al.
Publicado: (2014)

Synthesis and Incorporation of the Phosphoramidite Derivative of 2′-O-Photocaged 3′-S-Thioguanosine into Oligoribonucleotides: Substrate for Probing the Mechanism of RNA Catalysis
por: Li, Nan-Sheng, et al.
Publicado: (2014)

Thiopurines in Inflammatory Bowel Disease. How to Optimize Thiopurines in the Biologic Era?
por: Gargallo-Puyuelo, Carla J., et al.
Publicado: (2021)

No evidence for epitranscriptomic m(5)C modification of SARS-CoV-2, HIV and MLV viral RNA
por: Huang, Anming, et al.
Publicado: (2023)

Impact of NUDT15 polymorphisms on thiopurines-induced myelotoxicity and thiopurines tolerance dose
por: Yin, Dandan, et al.
Publicado: (2017)

Thiopurine S-Methyltransferase and Methylenetetrahydrofolate Reductase Polymorphisms in Leukemia
por: KÜPELİ, Serhan
Publicado: (2015)

A novel cytarabine crystalline lipid prodrug: Hexadecyloxypropyl cytarabine 3′,5′-cyclic monophosphate for proliferative vitreoretinopathy
por: Kim, Jae Suk, et al.
Publicado: (2012)

Ligand-induced folding of the thiM TPP riboswitch investigated by a structure-based fluorescence spectroscopic approach
por: Lang, Kathrin, et al.
Publicado: (2007)

Thiopurine methyltransferase genotype and thiopurine S-methyltransferase activity in Greek children with inflammatory bowel disease
por: Gazouli, Μaria, et al.
Publicado: (2012)

Pharmacogenetic studies of thiopurine methyltransferase genotype‐phenotype concordance and effect of methotrexate on thiopurine metabolism
por: Zimdahl Kahlin, Anna, et al.
Publicado: (2020)

Thiopurine dose intensity and treatment outcome in childhood lymphoblastic leukaemia: the influence of thiopurine methyltransferase pharmacogenetics
por: Lennard, Lynne, et al.
Publicado: (2014)

Thiopurine methyltransferase polymorphisms in children with acute lymphoblastic leukemia
por: Linga, Vijay Gandhi, et al.
Publicado: (2014)

Involvement of CYP4F2 in the Metabolism of a Novel Monophosphate Ester Prodrug of Gemcitabine and Its Interaction Potential In Vitro
por: Wang, Yedong, et al.
Publicado: (2018)

Thiopurine Drugs Repositioned as Tyrosinase Inhibitors
por: Choi, Joonhyeok, et al.
Publicado: (2017)

Thiopurines Analogues with Additional Ring: Synthesis, Spectroscopic Properties, and Anticancer Potency
por: Krancewicz, Katarzyna, et al.
Publicado: (2023)

Impaired Contextual Fear Extinction Learning is Associated with Aberrant Regulation of CHD-Type Chromatin Remodeling Factors
por: Wille, Alexandra, et al.
Publicado: (2015)

Safety and Efficacy of Split-Dose Thiopurine vs Low-Dose Thiopurine-Allopurinol Cotherapy in Pediatric Inflammatory Bowel Disease
por: Cococcioni, Lucia, et al.
Publicado: (2022)

Regulation of sensory perception and motor abilities by brain-specific action of chromatin remodeling factor CHD1
por: Schoberleitner, Ines, et al.
Publicado: (2022)

Thiopurine methyltransferase genotyping in Palestinian childhood acute lymphoblastic leukemia patients
por: Ayesh, Basim Mohammad, et al.
Publicado: (2013)

Genetic Polymorphism of Thiopurine S-methyltransferase in Children with Acute Lymphoblastic Leukemia in Jordan
por: Alsous, Mervat, et al.
Publicado: (2018)

Pharmacogenetic testing for thiopurine drugs in Brazilian acute lymphoblastic leukemia patients
por: Suarez-Kurtz, Guilherme, et al.
Publicado: (2023)

Thiopurine S-Methyltransferase Polymorphisms in Korean Dermatologic Patients
por: Lee, Minseok, et al.
Publicado: (2017)

Importance of NUDT15 Polymorphisms in Thiopurine Treatments
por: Tanaka, Yoichi, et al.
Publicado: (2021)

Use of thiopurines in inflammatory bowel disease: an update
por: Singh, Arshdeep, et al.
Publicado: (2022)

Long non-coding RNAs as targets for cytosine methylation
por: Amort, Thomas, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_nnt66q2r28eebccjkr05qthqih