Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites—Halogenated Probes of Druglike and Peptide-like Molecular Interactions

[Image: see text] The development of ligands for biological targets is critically dependent on the identification of sites on proteins that bind molecules with high affinity. A set of compounds, called FragLites, can identify such sites, along with the interactions required to gain affinity, by X-ra...

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Detalles Bibliográficos
Autores principales: Davison, Gemma, Martin, Mathew P., Turberville, Shannon, Dormen, Selma, Heath, Richard, Heptinstall, Amy B., Lawson, Marie, Miller, Duncan C., Ng, Yi Min, Sanderson, James N., Hope, Ian, Wood, Daniel J., Cano, Céline, Endicott, Jane A., Hardcastle, Ian R., Noble, Martin E. M., Waring, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706561/
https://www.ncbi.nlm.nih.gov/pubmed/36367089
http://dx.doi.org/10.1021/acs.jmedchem.2c01357

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706561/
https://www.ncbi.nlm.nih.gov/pubmed/36367089
http://dx.doi.org/10.1021/acs.jmedchem.2c01357

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