Development of Macrocyclic PRMT5–Adaptor Protein Interaction Inhibitors

[Image: see text] The PRMT5-MEP50 methyltransferase is a major target for anticancer drug discovery, and modulators of its interactions with different regulatory proteins are in high demand because they modulate PRMT5 substrate selectivity. We describe a strategy for the development of a PRMT5/adapt...

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Detalles Bibliográficos
Autores principales: Krzyzanowski, Adrian, Esser, Lea Marie, Willaume, Anthony, Prudent, Renaud, Peter, Christoph, ‘t Hart, Peter, Waldmann, Herbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706563/
https://www.ncbi.nlm.nih.gov/pubmed/36378254
http://dx.doi.org/10.1021/acs.jmedchem.2c01273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706563/
https://www.ncbi.nlm.nih.gov/pubmed/36378254
http://dx.doi.org/10.1021/acs.jmedchem.2c01273

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