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Development of Macrocyclic PRMT5–Adaptor Protein Interaction Inhibitors
[Image: see text] The PRMT5-MEP50 methyltransferase is a major target for anticancer drug discovery, and modulators of its interactions with different regulatory proteins are in high demand because they modulate PRMT5 substrate selectivity. We describe a strategy for the development of a PRMT5/adapt...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706563/ https://www.ncbi.nlm.nih.gov/pubmed/36378254 http://dx.doi.org/10.1021/acs.jmedchem.2c01273 |