A Versatile and Sustainable Multicomponent Platform for the Synthesis of Protein Degraders: Proof-of-Concept Application to BRD4-Degrading PROTACs

[Image: see text] The use of small molecules to induce targeted protein degradation is increasingly growing in the drug discovery landscape, and protein degraders have progressed rapidly through the pipelines. Despite the advances made so far, their synthesis still represents a significant burden an...

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Detalles Bibliográficos
Autores principales: Bhela, Irene Preet, Ranza, Alice, Balestrero, Federica Carolina, Serafini, Marta, Aprile, Silvio, Di Martino, Rita Maria Concetta, Condorelli, Fabrizio, Pirali, Tracey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706574/
https://www.ncbi.nlm.nih.gov/pubmed/36323630
http://dx.doi.org/10.1021/acs.jmedchem.2c01218

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706574/
https://www.ncbi.nlm.nih.gov/pubmed/36323630
http://dx.doi.org/10.1021/acs.jmedchem.2c01218

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