Assessing production variability in empty and filled adeno-associated viruses by single molecule mass analyses

Adeno-associated viruses (AAVs) are useful vehicles for gene therapy because of their stability, low immunogenicity. and non-pathogenicity. However, disparity in AAV sample preparations (e.g., in capsid composition, DNA packaging, and impurities) gives rise to product heterogeneity, with possibly un...

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Detalles Bibliográficos
Autores principales: Ebberink, Eduard H.T.M., Ruisinger, Alisa, Nuebel, Markus, Thomann, Marco, Heck, Albert J.R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706604/
https://www.ncbi.nlm.nih.gov/pubmed/36458114
http://dx.doi.org/10.1016/j.omtm.2022.11.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706604/
https://www.ncbi.nlm.nih.gov/pubmed/36458114
http://dx.doi.org/10.1016/j.omtm.2022.11.003

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