OR07-5 PARP1 Contributes to the Glucocorticoid Receptor Transcriptional Response And Influences the Skeletal Muscle Phenotype

BACKGROUND: NAD+-dependent PARP1 (Poly-(ADP-ribosyl)polymerase 1) generates the post-translational modification ADP-Ribosylation (ADPR). Given PARP1-ADPR determines cellular NAD+ availability, which in turn impacts a range of hormonally governed actions, we sought to identify the molecular roles of...

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Detalles Bibliográficos
Autores principales: Boocock, David, Coveney, Clare, Creighton, Jade, Doig, Craig, Sale, Craig, Weir, Nick, Younis, Awais, Tan, Arnold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Steroid Hormones and Receptors
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706615/
http://dx.doi.org/10.1210/jendso/bvac150.1492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706615/
http://dx.doi.org/10.1210/jendso/bvac150.1492

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