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Aryloxypropanolamine targets amyloid aggregates and reverses Alzheimer-like phenotypes in Alzheimer mouse models
BACKGROUND: Aggregated amyloid-β (Aβ) is considered a pathogenic initiator of Alzheimer’s disease (AD), in strong association with tau hyperphosphorylation, neuroinflammation, synaptic dysfunction, and cognitive decline. As the removal of amyloid burden from AD patient brains by antibodies has shown...
Autores principales: | Lee, Hee Yang, Yoon, Soljee, Lee, Jeong Hwa, Park, Keunwan, Jung, Youngeun, Cho, Illhwan, Lee, Donghee, Shin, Jisu, Kim, Kyeonghwan, Kim, Sunmi, Kim, Jimin, Kim, Koeun, Han, Seung Hoon, Kim, Seong Muk, Kim, Hye Ju, Kim, Hye Yun, Kim, Ikyon, Kim, Young Soo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706920/ https://www.ncbi.nlm.nih.gov/pubmed/36443837 http://dx.doi.org/10.1186/s13195-022-01112-6 |
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