Optimal construction of a functional interaction network from pooled library CRISPR fitness screens

BACKGROUND: Functional interaction networks, where edges connect genes likely to operate in the same biological process or pathway, can be inferred from CRISPR knockout screens in cancer cell lines. Genes with similar knockout fitness profiles across a sufficiently diverse set of cell line screens a...

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Detalles Bibliográficos
Autores principales: Gheorghe, Veronica, Hart, Traver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707256/
https://www.ncbi.nlm.nih.gov/pubmed/36443674
http://dx.doi.org/10.1186/s12859-022-05078-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707256/
https://www.ncbi.nlm.nih.gov/pubmed/36443674
http://dx.doi.org/10.1186/s12859-022-05078-y

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