Mutant huntingtin messenger RNA forms neuronal nuclear clusters in rodent and human brains

Mutant messenger RNA (mRNA) and protein contribute to the clinical manifestation of many repeat-associated neurological disorders, with the presence of nuclear RNA clusters being a common pathological feature. Yet, investigations into Huntington’s disease—caused by a CAG repeat expansion in exon 1 o...

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Detalles Bibliográficos
Autores principales: Ly, Socheata, Didiot, Marie-Cécile, Ferguson, Chantal M, Coles, Andrew H, Miller, Rachael, Chase, Kathryn, Echeverria, Dimas, Wang, Feng, Sadri-Vakili, Ghazaleh, Aronin, Neil, Khvorova, Anastasia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707646/
https://www.ncbi.nlm.nih.gov/pubmed/36458209
http://dx.doi.org/10.1093/braincomms/fcac248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707646/
https://www.ncbi.nlm.nih.gov/pubmed/36458209
http://dx.doi.org/10.1093/braincomms/fcac248

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