ATP13A2 modifies mitochondrial localization of overexpressed TOM20 to autolysosomal pathway

Mutations in ATP13A2 cause Kufor-Rakeb Syndrome (KRS), a juvenile form of Parkinson’s Disease (PD). The gene product belongs to a diverse family of ion pumps and mediates polyamine influx from lysosomal lumen. While the biochemical and structural studies highlight its unique mechanics, how PD pathol...

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Detalles Bibliográficos
Autores principales: Hatori, Yuta, Kanda, Yukina, Nonaka, Saori, Nakanishi, Hiroshi, Kitazawa, Takeo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707766/
https://www.ncbi.nlm.nih.gov/pubmed/36445873
http://dx.doi.org/10.1371/journal.pone.0276823

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707766/
https://www.ncbi.nlm.nih.gov/pubmed/36445873
http://dx.doi.org/10.1371/journal.pone.0276823

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