Age‐Independent Cardiac Protection by Pharmacological Activation of Beclin‐1 During Endotoxemia and Its Association With Energy Metabolic Reprograming in Myocardium—A Targeted Metabolomics Study

BACKGROUND: We showed that Beclin‐1‐dependent autophagy protects the heart in young and adult mice that underwent endotoxemia. Herein, we compared the potential therapeutic effects of Beclin‐1 activating peptide, TB‐peptide, on endotoxemia‐induced cardiac outcomes in young adult and aged mice. We fu...

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Detalles Bibliográficos
Autores principales: Kim, Matthew, Nikouee, Azadeh, Zou, Raymond, Ren, Di, He, Zhibin, Li, Ji, Wang, Lu, Djukovic, Danijel, Raftery, Daniel, Purcell, Hayley, Promislow, Daniel, Sun, Yuxiao, Goodarzi, Mohammad, Zhang, Qing‐Jun, Liu, Zhi‐Ping, Zang, Qun Sophia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707816/
https://www.ncbi.nlm.nih.gov/pubmed/35861821
http://dx.doi.org/10.1161/JAHA.122.025310

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707816/
https://www.ncbi.nlm.nih.gov/pubmed/35861821
http://dx.doi.org/10.1161/JAHA.122.025310

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