A motor neuron disease-associated mutation produces non-glycosylated Seipin that induces ER stress and apoptosis by inactivating SERCA2b

A causal relationship between endoplasmic reticulum (ER) stress and the development of neurodegenerative diseases remains controversial. Here, we focused on Seipinopathy, a dominant motor neuron disease, based on the finding that its causal gene product, Seipin, is a protein that spans the ER membra...

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Detalles Bibliográficos
Autores principales: Saito, Shunsuke, Ishikawa, Tokiro, Ninagawa, Satoshi, Okada, Tetsuya, Mori, Kazutoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708084/
https://www.ncbi.nlm.nih.gov/pubmed/36444643
http://dx.doi.org/10.7554/eLife.74805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708084/
https://www.ncbi.nlm.nih.gov/pubmed/36444643
http://dx.doi.org/10.7554/eLife.74805

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