Incidence of relapse of inflammatory protein‐losing enteropathy in dogs and associated risk factors

BACKGROUND: Dogs with inflammatory protein‐losing enteropathy (iPLE) that attain remission may be at risk of subsequent relapse. OBJECTIVES: To determine the incidence of relapse of iPLE in dogs that have previously attained complete clinical and biochemical remission and identify associated risk fa...

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Autores principales: Green, Jodie, Kathrani, Aarti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708386/
https://www.ncbi.nlm.nih.gov/pubmed/36207819
http://dx.doi.org/10.1111/jvim.16561
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author Green, Jodie
Kathrani, Aarti
author_facet Green, Jodie
Kathrani, Aarti
author_sort Green, Jodie
collection PubMed
description BACKGROUND: Dogs with inflammatory protein‐losing enteropathy (iPLE) that attain remission may be at risk of subsequent relapse. OBJECTIVES: To determine the incidence of relapse of iPLE in dogs that have previously attained complete clinical and biochemical remission and identify associated risk factors. ANIMALS: Seventy‐five client‐owned dogs diagnosed with iPLE. METHODS: Medical records of dogs diagnosed with iPLE based on histopathology of intestinal biopsy specimens between March 2010 and March 2020 were retrospectively reviewed. Variables were recorded from the time of investigation at histopathologic diagnosis and subsequent follow‐up information was obtained from the records of referring veterinarians. RESULTS: Twenty‐three dogs (31%) achieved sustained remission without documentation of relapse for at least 2 years. Nineteen dogs (25%) achieved remission, but then subsequently relapsed within 2 years of histopathologic diagnosis, and 33 dogs (44%) never achieved remission with disease‐associated death occurring a median of 19 (range, 3‐114) days after histopathologic diagnosis. Dogs that achieved remission and subsequently relapsed had significantly higher poor dietary compliance, as defined by frequent scavenging or changing from the recommended diet compared to dogs with sustained remission (P = .01). CONCLUSIONS: Inflammatory PLE is associated with a high rate of relapse in dogs. Ensuring owners adhere to dietary recommendations might help prevent subsequent relapse in dogs with iPLE that attain initial remission.
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spelling pubmed-97083862022-12-02 Incidence of relapse of inflammatory protein‐losing enteropathy in dogs and associated risk factors Green, Jodie Kathrani, Aarti J Vet Intern Med SMALL ANIMAL BACKGROUND: Dogs with inflammatory protein‐losing enteropathy (iPLE) that attain remission may be at risk of subsequent relapse. OBJECTIVES: To determine the incidence of relapse of iPLE in dogs that have previously attained complete clinical and biochemical remission and identify associated risk factors. ANIMALS: Seventy‐five client‐owned dogs diagnosed with iPLE. METHODS: Medical records of dogs diagnosed with iPLE based on histopathology of intestinal biopsy specimens between March 2010 and March 2020 were retrospectively reviewed. Variables were recorded from the time of investigation at histopathologic diagnosis and subsequent follow‐up information was obtained from the records of referring veterinarians. RESULTS: Twenty‐three dogs (31%) achieved sustained remission without documentation of relapse for at least 2 years. Nineteen dogs (25%) achieved remission, but then subsequently relapsed within 2 years of histopathologic diagnosis, and 33 dogs (44%) never achieved remission with disease‐associated death occurring a median of 19 (range, 3‐114) days after histopathologic diagnosis. Dogs that achieved remission and subsequently relapsed had significantly higher poor dietary compliance, as defined by frequent scavenging or changing from the recommended diet compared to dogs with sustained remission (P = .01). CONCLUSIONS: Inflammatory PLE is associated with a high rate of relapse in dogs. Ensuring owners adhere to dietary recommendations might help prevent subsequent relapse in dogs with iPLE that attain initial remission. John Wiley & Sons, Inc. 2022-10-07 2022 /pmc/articles/PMC9708386/ /pubmed/36207819 http://dx.doi.org/10.1111/jvim.16561 Text en © 2022 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle SMALL ANIMAL
Green, Jodie
Kathrani, Aarti
Incidence of relapse of inflammatory protein‐losing enteropathy in dogs and associated risk factors
title Incidence of relapse of inflammatory protein‐losing enteropathy in dogs and associated risk factors
title_full Incidence of relapse of inflammatory protein‐losing enteropathy in dogs and associated risk factors
title_fullStr Incidence of relapse of inflammatory protein‐losing enteropathy in dogs and associated risk factors
title_full_unstemmed Incidence of relapse of inflammatory protein‐losing enteropathy in dogs and associated risk factors
title_short Incidence of relapse of inflammatory protein‐losing enteropathy in dogs and associated risk factors
title_sort incidence of relapse of inflammatory protein‐losing enteropathy in dogs and associated risk factors
topic SMALL ANIMAL
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708386/
https://www.ncbi.nlm.nih.gov/pubmed/36207819
http://dx.doi.org/10.1111/jvim.16561
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