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PINK1-mediated mitophagy contributes to glucocorticoid-induced cathepsin K production in osteocytes

BACKGROUND: Glucocorticoid (GC) is one of frequently used anti-inflammatory agents, but its administration is unfortunately accompanied with bone loss. Although sporadic studies indicated that osteocytes are subject to a series of pathological changes under GC stress, including overexpression of cat...

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Detalles Bibliográficos
Autores principales: Yuan, Jun, Gao, You-shui, Liu, De-lin, Pang Tai, Andrew Chi, Zhou, Hong, Papadimitriou, John M., Zhang, Chang-qing, Zheng, Ming-hao, Gao, Jun-jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Speaking Orthopaedic Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708541/
https://www.ncbi.nlm.nih.gov/pubmed/36474855
http://dx.doi.org/10.1016/j.jot.2022.11.003