Validity of a two-antibody testing algorithm for mismatch repair deficiency testing in cancer; a systematic literature review and meta-analysis

Reflex mismatch repair immunohistochemistry (MMR IHC) testing for MLH1, PMS2, MSH2 and MSH6 is used to screen for Lynch syndrome. Recently MMR-deficiency (MMRd) has been approved as a pan-cancer predictive biomarker for checkpoint inhibitor therapy, leading to a vast increase in the use of MMR IHC i...

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Detalles Bibliográficos
Autores principales: Aiyer, K. T. S., Doeleman, T., Ryan, N. A., Nielsen, M., Crosbie, E. J., Smit, V. T. H. B. M., Morreau, H., Goeman, J. J., Bosse, T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708570/
https://www.ncbi.nlm.nih.gov/pubmed/36104536
http://dx.doi.org/10.1038/s41379-022-01149-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708570/
https://www.ncbi.nlm.nih.gov/pubmed/36104536
http://dx.doi.org/10.1038/s41379-022-01149-w

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