Ultra-rare and common genetic variant analysis converge to implicate negative selection and neuronal processes in the aetiology of schizophrenia

Both common and rare genetic variants (minor allele frequency >1% and <0.1% respectively) have been implicated in the aetiology of schizophrenia. In this study, we integrate single-cell gene expression data with publicly available Genome-Wide Association Study (GWAS) and exome sequenced data i...

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Detalles Bibliográficos
Autores principales: Akingbuwa, Wonuola A., Hammerschlag, Anke R., Bartels, Meike, Nivard, Michel G., Middeldorp, Christel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708595/
https://www.ncbi.nlm.nih.gov/pubmed/35665764
http://dx.doi.org/10.1038/s41380-022-01621-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708595/
https://www.ncbi.nlm.nih.gov/pubmed/35665764
http://dx.doi.org/10.1038/s41380-022-01621-8

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