Zn(II) binding to pramlintide results in a structural kink, fibril formation and antifungal activity

The antimicrobial properties of amylin, a 37-amino acid peptide hormone, co-secreted with insulin from the pancreas, are far less known than its antidiabetic function. We provide insight into the bioinorganic chemistry of amylin analogues, showing that the coordination of zinc(II) enhances the antif...

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Detalles Bibliográficos
Autores principales: Dudek, Dorota, Dzień, Emilia, Wątły, Joanna, Matera-Witkiewicz, Agnieszka, Mikołajczyk, Aleksandra, Hajda, Agata, Olesiak-Bańska, Joanna, Rowińska-Żyrek, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708664/
https://www.ncbi.nlm.nih.gov/pubmed/36446825
http://dx.doi.org/10.1038/s41598-022-24968-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708664/
https://www.ncbi.nlm.nih.gov/pubmed/36446825
http://dx.doi.org/10.1038/s41598-022-24968-y

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