Development of a multiplex allele-specific qPCR approach for testing PIK3CA mutations in patients with colorectal cancer

Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases involved in cellular growth and division. Somatic mutations in one of the PI3K catalytic subunit genes, PIK3CA, are frequently found in numerous malignancies, including colorectal cancer (CRC). Several PIK3CA inhibitors are approved for the tr...

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Detalles Bibliográficos
Autores principales: Oscorbin, Igor P., Beginyazova, Oguljan P., Khlistun, Inna V., Shamovskaya, Darya V., Oskina, Natalia A., Filipenko, Maxim L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708691/
https://www.ncbi.nlm.nih.gov/pubmed/36468132
http://dx.doi.org/10.1016/j.heliyon.2022.e11804

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708691/
https://www.ncbi.nlm.nih.gov/pubmed/36468132
http://dx.doi.org/10.1016/j.heliyon.2022.e11804

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