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PERIOD 2 regulates low-dose radioprotection via PER2/pGSK3β/β-catenin/Per2 loop
During evolution, humans are acclimatized to the stresses of natural radiation and circadian rhythmicity. Radiosensitivity of mammalian cells varies in the circadian period and adaptive radioprotection can be induced by pre-exposure to low-level radiation (LDR). It is unclear, however, if clock prot...
Autores principales: | Alexandrou, Aris T., Duan, Yixin, Xu, Shanxiu, Tepper, Clifford, Fan, Ming, Tang, Jason, Berg, Jonathan, Basheer, Wassim, Valicenti, Tyler, Wilson, Paul F., Coleman, Matthew A., Vaughan, Andrew T., Fu, Loning, Grdina, David J., Murley, Jefferey, Wang, Aijun, Woloschak, Gayle, Li, Jian Jian |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708791/ https://www.ncbi.nlm.nih.gov/pubmed/36465103 http://dx.doi.org/10.1016/j.isci.2022.105546 |
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