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IL6 supports long-term expansion of hepatocytes in vitro

Hepatocytes are very difficult to expand in vitro. A few studies have demonstrated that chemical cocktails with growth factors or Wnt ligands can support long-term expansion of hepatocytes via dedifferentiation. However, the culture conditions are complex, and clonal expansion of hepatic progenitors...

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Detalles Bibliográficos
Autores principales: Guo, Ren, Jiang, Mengmeng, Wang, Gang, Li, Bing, Jia, Xiaohui, Ai, Yan, Chen, Shanshan, Tang, Peilan, Liu, Aijie, Yuan, Qianting, Xie, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708838/
https://www.ncbi.nlm.nih.gov/pubmed/36446858
http://dx.doi.org/10.1038/s41467-022-35167-8