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The dichotomous outcomes of TNFα signaling in CD4(+) T cells
TNFa blocking agents were the first-in-class biologic drugs used for the treatment of autoimmune disease. Paradoxically, however, exacerbation of autoimmunity was observed in some patients. TNFa is a pleiotropic cytokine that has both proinflammatory and regulatory effects on CD4(+) T cells and can...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708889/ https://www.ncbi.nlm.nih.gov/pubmed/36466853 http://dx.doi.org/10.3389/fimmu.2022.1042622 |