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The dichotomous outcomes of TNFα signaling in CD4(+) T cells

TNFa blocking agents were the first-in-class biologic drugs used for the treatment of autoimmune disease. Paradoxically, however, exacerbation of autoimmunity was observed in some patients. TNFa is a pleiotropic cytokine that has both proinflammatory and regulatory effects on CD4(+) T cells and can...

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Detalles Bibliográficos
Autores principales:	Skartsis, Nikolaos, Ferreira, Leonardo M. R., Tang, Qizhi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708889/ https://www.ncbi.nlm.nih.gov/pubmed/36466853 http://dx.doi.org/10.3389/fimmu.2022.1042622

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