Overexpression of Wild‐Type ACVR1 in Fibrodysplasia Ossificans Progressiva Mice Rescues Perinatal Lethality and Inhibits Heterotopic Ossification

Fibrodysplasia ossificans progressiva (FOP) is a devastating disease of progressive heterotopic bone formation for which effective treatments are currently unavailable. FOP is caused by dominant gain‐of‐function mutations in the receptor ACVR1 (also known as ALK2), which render the receptor inapprop...

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Detalles Bibliográficos
Autores principales: Yamamoto, Masakazu, Stoessel, Sean J, Yamamoto, Shoko, Goldhamer, David J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708949/
https://www.ncbi.nlm.nih.gov/pubmed/35637634
http://dx.doi.org/10.1002/jbmr.4617

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708949/
https://www.ncbi.nlm.nih.gov/pubmed/35637634
http://dx.doi.org/10.1002/jbmr.4617

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