Ablation of Shank3 alleviates cardiac dysfunction in aging mice by promoting CaMKII activation and Parkin-mediated mitophagy()

Compromised mitophagy and mitochondrial homeostasis are major contributors for the etiology of cardiac aging, although the precise underlying mechanisms remains elusive. Shank3, a heart-enriched protein, has recently been reported to regulate aging-related neurodegenerative diseases. This study aime...

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Detalles Bibliográficos
Autores principales: Wang, Ying, Xu, Yuerong, Guo, Wangang, Fang, Yexian, Hu, Lang, Wang, Runze, Zhao, Ran, Guo, Dong, Qi, Bingchao, Ren, Gaotong, Ren, Jun, Li, Yan, Zhang, Mingming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709154/
https://www.ncbi.nlm.nih.gov/pubmed/36436456
http://dx.doi.org/10.1016/j.redox.2022.102537

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709154/
https://www.ncbi.nlm.nih.gov/pubmed/36436456
http://dx.doi.org/10.1016/j.redox.2022.102537

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