Mitochondrial succinate dehydrogenase function is essential for sperm motility and male fertility
Mitochondrial health is crucial to sperm quality and male fertility, but the precise role of mitochondria in sperm function remains unclear. SDHA is a component of the succinate dehydrogenase (SDH) complex and plays a critical role in mitochondria. In humans, SDH activity is positively correlated wi...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709242/ https://www.ncbi.nlm.nih.gov/pubmed/36465130 http://dx.doi.org/10.1016/j.isci.2022.105573 |
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author | Woodhouse, Rachel M. Frolows, Natalya Wang, Guoqiang Hawdon, Azelle Wong, Edmund Heng Kin Dansereau, Linda C. Su, Yingying Adair, Liam D. New, Elizabeth J. Philp, Ashleigh M. Tan, Wei Kang Philp, Andrew Ashe, Alyson |
author_facet | Woodhouse, Rachel M. Frolows, Natalya Wang, Guoqiang Hawdon, Azelle Wong, Edmund Heng Kin Dansereau, Linda C. Su, Yingying Adair, Liam D. New, Elizabeth J. Philp, Ashleigh M. Tan, Wei Kang Philp, Andrew Ashe, Alyson |
author_sort | Woodhouse, Rachel M. |
collection | PubMed |
description | Mitochondrial health is crucial to sperm quality and male fertility, but the precise role of mitochondria in sperm function remains unclear. SDHA is a component of the succinate dehydrogenase (SDH) complex and plays a critical role in mitochondria. In humans, SDH activity is positively correlated with sperm quality, and mutations in SDHA are associated with Leigh Syndrome. Here we report that the C. elegans SDHA orthologue SDHA-2 is essential for male fertility: sdha-2 mutants produce dramatically fewer offspring due to defective sperm activation and motility, have hyperfused sperm mitochondria, and disrupted redox balance. Similar sperm motility defects in sdha-1 and icl-1 mutant animals suggest an imbalance in metabolites may underlie the fertility defect. Our results demonstrate a role for SDHA-2 in sperm motility and male reproductive health and establish an animal model of SDH deficiency-associated infertility. |
format | Online Article Text |
id | pubmed-9709242 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-97092422022-12-01 Mitochondrial succinate dehydrogenase function is essential for sperm motility and male fertility Woodhouse, Rachel M. Frolows, Natalya Wang, Guoqiang Hawdon, Azelle Wong, Edmund Heng Kin Dansereau, Linda C. Su, Yingying Adair, Liam D. New, Elizabeth J. Philp, Ashleigh M. Tan, Wei Kang Philp, Andrew Ashe, Alyson iScience Article Mitochondrial health is crucial to sperm quality and male fertility, but the precise role of mitochondria in sperm function remains unclear. SDHA is a component of the succinate dehydrogenase (SDH) complex and plays a critical role in mitochondria. In humans, SDH activity is positively correlated with sperm quality, and mutations in SDHA are associated with Leigh Syndrome. Here we report that the C. elegans SDHA orthologue SDHA-2 is essential for male fertility: sdha-2 mutants produce dramatically fewer offspring due to defective sperm activation and motility, have hyperfused sperm mitochondria, and disrupted redox balance. Similar sperm motility defects in sdha-1 and icl-1 mutant animals suggest an imbalance in metabolites may underlie the fertility defect. Our results demonstrate a role for SDHA-2 in sperm motility and male reproductive health and establish an animal model of SDH deficiency-associated infertility. Elsevier 2022-11-14 /pmc/articles/PMC9709242/ /pubmed/36465130 http://dx.doi.org/10.1016/j.isci.2022.105573 Text en © 2022 The Authors. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Woodhouse, Rachel M. Frolows, Natalya Wang, Guoqiang Hawdon, Azelle Wong, Edmund Heng Kin Dansereau, Linda C. Su, Yingying Adair, Liam D. New, Elizabeth J. Philp, Ashleigh M. Tan, Wei Kang Philp, Andrew Ashe, Alyson Mitochondrial succinate dehydrogenase function is essential for sperm motility and male fertility |
title | Mitochondrial succinate dehydrogenase function is essential for sperm motility and male fertility |
title_full | Mitochondrial succinate dehydrogenase function is essential for sperm motility and male fertility |
title_fullStr | Mitochondrial succinate dehydrogenase function is essential for sperm motility and male fertility |
title_full_unstemmed | Mitochondrial succinate dehydrogenase function is essential for sperm motility and male fertility |
title_short | Mitochondrial succinate dehydrogenase function is essential for sperm motility and male fertility |
title_sort | mitochondrial succinate dehydrogenase function is essential for sperm motility and male fertility |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709242/ https://www.ncbi.nlm.nih.gov/pubmed/36465130 http://dx.doi.org/10.1016/j.isci.2022.105573 |
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