Mitochondrial succinate dehydrogenase function is essential for sperm motility and male fertility

Mitochondrial health is crucial to sperm quality and male fertility, but the precise role of mitochondria in sperm function remains unclear. SDHA is a component of the succinate dehydrogenase (SDH) complex and plays a critical role in mitochondria. In humans, SDH activity is positively correlated wi...

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Autores principales: Woodhouse, Rachel M., Frolows, Natalya, Wang, Guoqiang, Hawdon, Azelle, Wong, Edmund Heng Kin, Dansereau, Linda C., Su, Yingying, Adair, Liam D., New, Elizabeth J., Philp, Ashleigh M., Tan, Wei Kang, Philp, Andrew, Ashe, Alyson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709242/
https://www.ncbi.nlm.nih.gov/pubmed/36465130
http://dx.doi.org/10.1016/j.isci.2022.105573
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author Woodhouse, Rachel M.
Frolows, Natalya
Wang, Guoqiang
Hawdon, Azelle
Wong, Edmund Heng Kin
Dansereau, Linda C.
Su, Yingying
Adair, Liam D.
New, Elizabeth J.
Philp, Ashleigh M.
Tan, Wei Kang
Philp, Andrew
Ashe, Alyson
author_facet Woodhouse, Rachel M.
Frolows, Natalya
Wang, Guoqiang
Hawdon, Azelle
Wong, Edmund Heng Kin
Dansereau, Linda C.
Su, Yingying
Adair, Liam D.
New, Elizabeth J.
Philp, Ashleigh M.
Tan, Wei Kang
Philp, Andrew
Ashe, Alyson
author_sort Woodhouse, Rachel M.
collection PubMed
description Mitochondrial health is crucial to sperm quality and male fertility, but the precise role of mitochondria in sperm function remains unclear. SDHA is a component of the succinate dehydrogenase (SDH) complex and plays a critical role in mitochondria. In humans, SDH activity is positively correlated with sperm quality, and mutations in SDHA are associated with Leigh Syndrome. Here we report that the C. elegans SDHA orthologue SDHA-2 is essential for male fertility: sdha-2 mutants produce dramatically fewer offspring due to defective sperm activation and motility, have hyperfused sperm mitochondria, and disrupted redox balance. Similar sperm motility defects in sdha-1 and icl-1 mutant animals suggest an imbalance in metabolites may underlie the fertility defect. Our results demonstrate a role for SDHA-2 in sperm motility and male reproductive health and establish an animal model of SDH deficiency-associated infertility.
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spelling pubmed-97092422022-12-01 Mitochondrial succinate dehydrogenase function is essential for sperm motility and male fertility Woodhouse, Rachel M. Frolows, Natalya Wang, Guoqiang Hawdon, Azelle Wong, Edmund Heng Kin Dansereau, Linda C. Su, Yingying Adair, Liam D. New, Elizabeth J. Philp, Ashleigh M. Tan, Wei Kang Philp, Andrew Ashe, Alyson iScience Article Mitochondrial health is crucial to sperm quality and male fertility, but the precise role of mitochondria in sperm function remains unclear. SDHA is a component of the succinate dehydrogenase (SDH) complex and plays a critical role in mitochondria. In humans, SDH activity is positively correlated with sperm quality, and mutations in SDHA are associated with Leigh Syndrome. Here we report that the C. elegans SDHA orthologue SDHA-2 is essential for male fertility: sdha-2 mutants produce dramatically fewer offspring due to defective sperm activation and motility, have hyperfused sperm mitochondria, and disrupted redox balance. Similar sperm motility defects in sdha-1 and icl-1 mutant animals suggest an imbalance in metabolites may underlie the fertility defect. Our results demonstrate a role for SDHA-2 in sperm motility and male reproductive health and establish an animal model of SDH deficiency-associated infertility. Elsevier 2022-11-14 /pmc/articles/PMC9709242/ /pubmed/36465130 http://dx.doi.org/10.1016/j.isci.2022.105573 Text en © 2022 The Authors. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Woodhouse, Rachel M.
Frolows, Natalya
Wang, Guoqiang
Hawdon, Azelle
Wong, Edmund Heng Kin
Dansereau, Linda C.
Su, Yingying
Adair, Liam D.
New, Elizabeth J.
Philp, Ashleigh M.
Tan, Wei Kang
Philp, Andrew
Ashe, Alyson
Mitochondrial succinate dehydrogenase function is essential for sperm motility and male fertility
title Mitochondrial succinate dehydrogenase function is essential for sperm motility and male fertility
title_full Mitochondrial succinate dehydrogenase function is essential for sperm motility and male fertility
title_fullStr Mitochondrial succinate dehydrogenase function is essential for sperm motility and male fertility
title_full_unstemmed Mitochondrial succinate dehydrogenase function is essential for sperm motility and male fertility
title_short Mitochondrial succinate dehydrogenase function is essential for sperm motility and male fertility
title_sort mitochondrial succinate dehydrogenase function is essential for sperm motility and male fertility
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709242/
https://www.ncbi.nlm.nih.gov/pubmed/36465130
http://dx.doi.org/10.1016/j.isci.2022.105573
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