Cargando…

Pigment epithelium-derived factor is an interleukin-6 antagonist in the RPE: Insight of structure-function relationships

Retinal and choroidal inflammatory lesions increase the levels of the pro-inflammatory cytokine interleukin-6 (IL-6). Pigment epithelium-derived factor (PEDF) has anti-inflammatory properties, but it is not known if it can prevent the production of IL-6 by the retinal pigment epithelium. To investig...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bernardo-Colón, Alexandra, Lerner, Miriam, Becerra, S. Patricia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709256/ https://www.ncbi.nlm.nih.gov/pubmed/36467689 http://dx.doi.org/10.3389/fphys.2022.1045613

Ejemplares similares

Degradation of Photoreceptor Outer Segments by the Retinal Pigment Epithelium Requires Pigment Epithelium-Derived Factor Receptor (PEDF-R)
por: Bullock, Jeanee, et al.
Publicado: (2021)

Age-Related Changes in the Retinal Pigment Epithelium (RPE)
por: Gu, Xiaorong, et al.
Publicado: (2012)

Proteomics of Human Retinal Pigment Epithelium (RPE) Cells
por: Beranova-Giorgianni, Sarka, et al.
Publicado: (2018)

Ablation of pigment epithelium-derived factor receptor (PEDF-R/Pnpla2) causes photoreceptor degeneration
por: Bernardo-Colón, Alexandra, et al.
Publicado: (2023)

Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors
por: Brown, Emily E., et al.
Publicado: (2019)

A Novel Inhibitor of 5-Lipoxygenase (5-LOX) Prevents Oxidative Stress–Induced Cell Death of Retinal Pigment Epithelium (RPE) Cells
por: Subramanian, Preeti, et al.
Publicado: (2016)

Selective Ablation of Dehydrodolichyl Diphosphate Synthase in Murine Retinal Pigment Epithelium (RPE) Causes RPE Atrophy and Retinal Degeneration
por: DeRamus, Marci L., et al.
Publicado: (2020)

DJ-1-Dependent Regulation of Oxidative Stress in the Retinal Pigment Epithelium (RPE)
por: Shadrach, Karen G., et al.
Publicado: (2013)

Cadherins in the retinal pigment epithelium (RPE) revisited: P-cadherin is the highly dominant cadherin expressed in human and mouse RPE in vivo
por: Yang, Xue, et al.
Publicado: (2018)

Correction: DJ-1-Dependent Regulation of Oxidative Stress in the Retinal Pigment Epithelium (RPE)
Publicado: (2014)

Magnetic Nanoparticles as Intraocular Drug Delivery System to Target Retinal Pigmented Epithelium (RPE)
por: Giannaccini, Martina, et al.
Publicado: (2014)

Impaired Cargo Clearance in the Retinal Pigment Epithelium (RPE) Underlies Irreversible Blinding Diseases
por: Keeling, Eloise, et al.
Publicado: (2018)

Correction: DJ-1-Dependent Regulation of Oxidative Stress in the Retinal Pigment Epithelium (RPE)
por: Shadrach, Karen G., et al.
Publicado: (2017)

Oxidative stress in the retina and retinal pigment epithelium (RPE): Role of aging, and DJ-1
por: Upadhyay, Mala, et al.
Publicado: (2020)

Mechanism of Nucleic Acid Sensing in Retinal Pigment Epithelium (RPE): RIG-I Mediates Type I Interferon Response in Human RPE
por: Schustak, Joshua, et al.
Publicado: (2021)

Ex-vivo models of the Retinal Pigment Epithelium (RPE) in long-term culture faithfully recapitulate key structural and physiological features of native RPE
por: Lynn, Savannah A., et al.
Publicado: (2017)

Conditional Loss of the Exocyst Component Exoc5 in Retinal Pigment Epithelium (RPE) Results in RPE Dysfunction, Photoreceptor Cell Degeneration, and Decreased Visual Function
por: Rohrer, Bärbel, et al.
Publicado: (2021)

Pigment Epithelium-Derived Factor: Chemistry, Structure, Biology, and Applications
por: Becerra, S. Patricia, et al.
Publicado: (2012)

Cellular and Molecular Preconditions for Retinal Pigment Epithelium (RPE) Natural Reprogramming during Retinal Regeneration in Urodela
por: Grigoryan, Eleonora N., et al.
Publicado: (2016)

That Escalated Quickly—Planning to Ignore RPE Can Backfire
por: Bieleke, Maik, et al.
Publicado: (2017)

In-Depth Characterisation of Retinal Pigment Epithelium (RPE) Cells Derived from Human Induced Pluripotent Stem Cells (hiPSC)
por: Brandl, Caroline, et al.
Publicado: (2014)

Dynamic human retinal pigment epithelium (RPE) and choroid architecture based on single-cell transcriptomic landscape analysis
por: Huang, Lulin, et al.
Publicado: (2022)

Retinal Pigment Epithelium Atrophy After Subretinal Voretigene Neparvovec-rzyl for RPE65-Related Disease: A 6-Month Follow-Up
por: Giansanti, Fabrizio, et al.
Publicado: (2022)

Beyond RPE: The Perception of Exercise Under Normal and Ketotic Conditions
por: Faull, Olivia K., et al.
Publicado: (2019)

Mechanisms of Ion Transport Across the Mouse Retinal Pigment Epithelium Measured In Vitro
por: Skarphedinsdottir, Sunna Bjorg, et al.
Publicado: (2020)

Daily zeaxanthin supplementation prevents atrophy of the retinal pigment epithelium (RPE) in a mouse model of mitochondrial oxidative stress
por: Biswal, Manas R., et al.
Publicado: (2018)

RPE and neuronal differentiation of allotransplantated porcine ciliary epithelium-derived cells
por: Guduric-Fuchs, Jasenka, et al.
Publicado: (2011)

Tumorigenicity Studies of Induced Pluripotent Stem Cell (iPSC)-Derived Retinal Pigment Epithelium (RPE) for the Treatment of Age-Related Macular Degeneration
por: Kanemura, Hoshimi, et al.
Publicado: (2014)

Loss of Extracellular Signal-Regulated Kinase 1/2 in the Retinal Pigment Epithelium Leads to RPE65 Decrease and Retinal Degeneration
por: Pyakurel, Aswin, et al.
Publicado: (2017)

Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration
por: Storti, Federica, et al.
Publicado: (2019)

Spontaneous generation of a novel foetal human retinal pigment epithelium (RPE) cell line available for investigation on phagocytosis and morphogenesis
por: Shao, Zhihua, et al.
Publicado: (2017)

RPE vs. Percentage 1RM Loading in Periodized Programs Matched for Sets and Repetitions
por: Helms, Eric R., et al.
Publicado: (2018)

Small Molecules Restore Bestrophin 1 Expression and Function of Both Dominant and Recessive Bestrophinopathies in Patient-Derived Retinal Pigment Epithelium
por: Liu, Jingshu, et al.
Publicado: (2020)

Microtubule Motor Transport of Organelles in a Specialized Epithelium: The RPE
por: Hazim, Roni A., et al.
Publicado: (2022)

Soluble Interleukin-6 Receptor Regulates Interleukin-6-Dependent Vascular Remodeling in Long-Distance Runners
por: Villar-Fincheira, Paulina, et al.
Publicado: (2021)

Ginsenoside Rg-1 Protects Retinal Pigment Epithelium (RPE) Cells from Cobalt Chloride (CoCl(2)) and Hypoxia Assaults
por: Li, Ke-ran, et al.
Publicado: (2013)

Relative Contribution of Different Mitochondrial Oxidative Phosphorylation Components to the Retinal Pigment Epithelium Barrier Function: Implications for RPE-Related Retinal Diseases
por: Guerra, Michael H., et al.
Publicado: (2021)

Glycosaminoglycans in human retinoblastoma cells: Heparan sulfate, a modulator of the pigment epithelium-derived factor-receptor interactions
por: Alberdi, Elena M, et al.
Publicado: (2003)

Imbalance Between Interleukin-1β and Interleukin-1 Receptor Antagonist in Epicardial Adipose Tissue Is Associated With Non ST-Segment Elevation Acute Coronary Syndrome
por: Parisi, Valentina, et al.
Publicado: (2020)

Pigment epithelium-derived factor hinders photoreceptor cell death by reducing intracellular calcium in the degenerating retina
por: Comitato, Antonella, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_2pa424p99895e1gm71c0ue4it1