Diagnostic and therapeutic potential of RNASET2 in Crohn’s disease: Disease-risk polymorphism modulates allelic-imbalance in expression and circulating protein levels and recombinant-RNASET2 attenuates pro-inflammatory cytokine secretion

Ribonuclease T2 gene (RNASET2) variants are associated in genome wide association studies (GWAS) with risk for several autoimmune diseases, including Crohn’s disease (CD). In T cells, a functional and biological relationship exists between TNFSF15-mediated enhancement of IFN−γ production, mucosal in...

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Detalles Bibliográficos
Autores principales: Biener-Ramanujan, Eva, Rosier, Florian, Coetzee, Simon G., McGovern, Dermot D. P., Hazelett, Dennis, Targan, Stephan R., Gonsky, Rivkah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709281/
https://www.ncbi.nlm.nih.gov/pubmed/36466822
http://dx.doi.org/10.3389/fimmu.2022.999155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709281/
https://www.ncbi.nlm.nih.gov/pubmed/36466822
http://dx.doi.org/10.3389/fimmu.2022.999155

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