A novel costimulatory molecule gene-modified leukemia cell-derived exosome-targeted CD4(+) T cell vaccine efficiently enhances anti-leukemia immunity

Previous studies demonstrated that CD4(+) T cells can uptake tumor antigen-pulsed dendritic cell-derived exosomes (DEXO), which harbor tumor antigen peptide/pMHC I complex and costimulatory molecules and show potent effects on inducing antitumor immunity. However, in preliminary study, CD4(+) T cell...

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Detalles Bibliográficos
Autores principales: Li, Jiaqi, Huang, Fang, Jiang, Yan, Zhao, Jie, Wan, Jiangbo, Hao, Siguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709463/
https://www.ncbi.nlm.nih.gov/pubmed/36466863
http://dx.doi.org/10.3389/fimmu.2022.1043484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709463/
https://www.ncbi.nlm.nih.gov/pubmed/36466863
http://dx.doi.org/10.3389/fimmu.2022.1043484

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