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A novel costimulatory molecule gene-modified leukemia cell-derived exosome-targeted CD4(+) T cell vaccine efficiently enhances anti-leukemia immunity
Previous studies demonstrated that CD4(+) T cells can uptake tumor antigen-pulsed dendritic cell-derived exosomes (DEXO), which harbor tumor antigen peptide/pMHC I complex and costimulatory molecules and show potent effects on inducing antitumor immunity. However, in preliminary study, CD4(+) T cell...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709463/ https://www.ncbi.nlm.nih.gov/pubmed/36466863 http://dx.doi.org/10.3389/fimmu.2022.1043484 |