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Endothelial progenitor cell-derived small extracellular vesicles for myocardial angiogenesis and revascularization

BACKGROUND: Endothelial progenitor cells (EPCs) have been well-studied for their differentiation potential and paracrine activity in vitro and in experimental animal studies. EPCs are the precursors of endothelial cells (ECs) and a rich source of pro-angiogenic factors, and hence, possess enormous p...

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Autores principales: Al-Omar, Maher T., Alnajjar, Mahmoud T., Ahmed, Ziyad T., Salaas, Faris M. I., Alrefaei, Tamim S. M., Haider, Khawaja H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Whioce Publishing Pte. Ltd. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709527/
https://www.ncbi.nlm.nih.gov/pubmed/36457898
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author Al-Omar, Maher T.
Alnajjar, Mahmoud T.
Ahmed, Ziyad T.
Salaas, Faris M. I.
Alrefaei, Tamim S. M.
Haider, Khawaja H.
author_facet Al-Omar, Maher T.
Alnajjar, Mahmoud T.
Ahmed, Ziyad T.
Salaas, Faris M. I.
Alrefaei, Tamim S. M.
Haider, Khawaja H.
author_sort Al-Omar, Maher T.
collection PubMed
description BACKGROUND: Endothelial progenitor cells (EPCs) have been well-studied for their differentiation potential and paracrine activity in vitro and in experimental animal studies. EPCs are the precursors of endothelial cells (ECs) and a rich source of pro-angiogenic factors, and hence, possess enormous potential to treat ischemic heart through myocardial angiogenesis. Their proven safety and efficacy observed during the pre-clinical and clinical studies have portrayed them as a near ideal cell type for cell-based therapy of ischemic heart disease.In response to the chemical cues from the ischemic heart, EPCs from the bone marrow and peripheral circulation home-in to the ischemic myocardium and participate in the intrinsic repair process at the molecular and cellular levels through paracrine activity and EC differentiation. EPCs also release small extracellular vesicles (sEVs) loaded with bioactive molecules as part of their paracrine activity for intercellular communication to participate in the reparative process in the heart. AIM: This literature review is based on the published data regarding the characteristic features of EPC-derived sEVs and their proteomic and genomic payload, besides facilitating safe and effective repair of the ischemic myocardium. In light of the encouraging published data, translational and clinical assessment of EPC-derived sEVs is warranted. We report the recent experimental animal studies and their findings using EPC-derived sEVs on cardiac angiogenesis and preservation of cardiac function. RELEVANCE FOR PATIENTS: With the promising results from pre-clinical studies, clinical trials should be conducted to assess the clinical utility of EPC-derived sEVs in the treatment of the ischemic myocardium.
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spelling pubmed-97095272022-11-30 Endothelial progenitor cell-derived small extracellular vesicles for myocardial angiogenesis and revascularization Al-Omar, Maher T. Alnajjar, Mahmoud T. Ahmed, Ziyad T. Salaas, Faris M. I. Alrefaei, Tamim S. M. Haider, Khawaja H. J Clin Transl Res Review Artilce BACKGROUND: Endothelial progenitor cells (EPCs) have been well-studied for their differentiation potential and paracrine activity in vitro and in experimental animal studies. EPCs are the precursors of endothelial cells (ECs) and a rich source of pro-angiogenic factors, and hence, possess enormous potential to treat ischemic heart through myocardial angiogenesis. Their proven safety and efficacy observed during the pre-clinical and clinical studies have portrayed them as a near ideal cell type for cell-based therapy of ischemic heart disease.In response to the chemical cues from the ischemic heart, EPCs from the bone marrow and peripheral circulation home-in to the ischemic myocardium and participate in the intrinsic repair process at the molecular and cellular levels through paracrine activity and EC differentiation. EPCs also release small extracellular vesicles (sEVs) loaded with bioactive molecules as part of their paracrine activity for intercellular communication to participate in the reparative process in the heart. AIM: This literature review is based on the published data regarding the characteristic features of EPC-derived sEVs and their proteomic and genomic payload, besides facilitating safe and effective repair of the ischemic myocardium. In light of the encouraging published data, translational and clinical assessment of EPC-derived sEVs is warranted. We report the recent experimental animal studies and their findings using EPC-derived sEVs on cardiac angiogenesis and preservation of cardiac function. RELEVANCE FOR PATIENTS: With the promising results from pre-clinical studies, clinical trials should be conducted to assess the clinical utility of EPC-derived sEVs in the treatment of the ischemic myocardium. Whioce Publishing Pte. Ltd. 2022-10-31 /pmc/articles/PMC9709527/ /pubmed/36457898 Text en Copyright: © 2022 Author(s). https://creativecommons.org/licenses/by-nc/4.0/This is an Open-Access article distributed under the terms of the Creative Commons Attribution-Noncommercial License, permitting all noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Artilce
Al-Omar, Maher T.
Alnajjar, Mahmoud T.
Ahmed, Ziyad T.
Salaas, Faris M. I.
Alrefaei, Tamim S. M.
Haider, Khawaja H.
Endothelial progenitor cell-derived small extracellular vesicles for myocardial angiogenesis and revascularization
title Endothelial progenitor cell-derived small extracellular vesicles for myocardial angiogenesis and revascularization
title_full Endothelial progenitor cell-derived small extracellular vesicles for myocardial angiogenesis and revascularization
title_fullStr Endothelial progenitor cell-derived small extracellular vesicles for myocardial angiogenesis and revascularization
title_full_unstemmed Endothelial progenitor cell-derived small extracellular vesicles for myocardial angiogenesis and revascularization
title_short Endothelial progenitor cell-derived small extracellular vesicles for myocardial angiogenesis and revascularization
title_sort endothelial progenitor cell-derived small extracellular vesicles for myocardial angiogenesis and revascularization
topic Review Artilce
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709527/
https://www.ncbi.nlm.nih.gov/pubmed/36457898
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