Cargando…

Discovery of novel thioquinazoline-N-aryl-acetamide/N-arylacetohydrazide hybrids as anti-SARS-CoV-2 agents: Synthesis, in vitro biological evaluation, and molecular docking studies

In the current investigation, two novel series of (tetrahydro)thioquinazoline-N-arylacetamides and (tetrahydro)thioquinazoline-N-arylacetohydrazides were designed, synthesized and investigated for their antiviral activity against SARS-CoV-2. The thioquinazoline-N-arylacetamide 17g as well as the tet...

Descripción completa

Detalles Bibliográficos
Autores principales:	Abdel-Mohsen, Heba T., Omar, Mohamed A., Kutkat, Omnia, Kerdawy, Ahmed M. El, Osman, Alaa A., GabAllah, Mohamed, Mostafa, Ahmed, Ali, Mohamed A., Diwani, Hoda I. El
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier B.V. 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709698/ https://www.ncbi.nlm.nih.gov/pubmed/36465802 http://dx.doi.org/10.1016/j.molstruc.2022.134690

Ejemplares similares

Aurasperone A Inhibits SARS CoV-2 In Vitro: An Integrated In Vitro and In Silico Study
por: ElNaggar, Mai H., et al.
Publicado: (2022)

Investigating the Potential Anti-SARS-CoV-2 and Anti-MERS-CoV Activities of Yellow Necklacepod among Three Selected Medicinal Plants: Extraction, Isolation, Identification, In Vitro, Modes of Action, and Molecular Docking Studies
por: Abd-Alla, Howaida I., et al.
Publicado: (2022)

Robust antiviral activity of commonly prescribed antidepressants against emerging coronaviruses: in vitro and in silico drug repurposing studies
por: Kutkat, Omnia, et al.
Publicado: (2022)

Impact of Individual Viral Gene Segments from Influenza A/H5N8 Virus on the Protective Efficacy of Inactivated Subtype-Specific Influenza Vaccine
por: Moatasim, Yassmin, et al.
Publicado: (2021)

Synthesis, Antiviral Bioactivity of Novel 4-Thioquinazoline Derivatives Containing Chalcone Moiety
por: Wan, Zhihua, et al.
Publicado: (2015)

Incidence, household transmission, and neutralizing antibody seroprevalence of Coronavirus Disease 2019 in Egypt: Results of a community-based cohort
por: Gomaa, Mokhtar R., et al.
Publicado: (2021)

Comparative pathogenic potential of avian influenza H7N3 viruses isolated from wild birds in Egypt and their sensitivity to commercial antiviral drugs
por: Kayed, Ahmed E., et al.
Publicado: (2023)

FDA-Approved Drugs with Potent In Vitro Antiviral Activity against Severe Acute Respiratory Syndrome Coronavirus 2
por: Mostafa, Ahmed, et al.
Publicado: (2020)

Potent Antiviral Activity of Vitamin B12 against Severe Acute Respiratory Syndrome Coronavirus 2, Middle East Respiratory Syndrome Coronavirus, and Human Coronavirus 229E
por: Moatasim, Yassmin, et al.
Publicado: (2023)

Crystal structures of three N-aryl-2,2,2-tribromoacetamides
por: Sreenivasa, S., et al.
Publicado: (2015)

Changes in Plasma Growth Differentiation Factor-15 After Laparoscopic Sleeve Gastrectomy in Morbidly Obese Patients: A Prospective Study
por: Salman, Ahmed, et al.
Publicado: (2021)

Insights into Genetic Characteristics and Virological Features of Endemic Avian Influenza A (H9N2) Viruses in Egypt from 2017–2021
por: El Sayes, Mohamed, et al.
Publicado: (2022)

Synthesis, Characterization, and Anticancer Activity of New N,N′-Diarylthiourea Derivative against Breast Cancer Cells
por: El-Atawy, Mohamed A., et al.
Publicado: (2023)

Targeting Receptor Tyrosine Kinase VEGFR-2 in Hepatocellular Cancer: Rational Design, Synthesis and Biological Evaluation of 1,2-Disubstituted Benzimidazoles
por: Abdel-Mohsen, Heba T., et al.
Publicado: (2020)

Novel 2-(5-Aryl-4,5-Dihydropyrazol-1-yl)thiazol-4-One as EGFR Inhibitors: Synthesis, Biological Assessment and Molecular Docking Insights
por: Al-Warhi, Tarfah, et al.
Publicado: (2022)

2-Cyano-N,N-dimethylacetamide
por: Liu, Shan, et al.
Publicado: (2012)

2-Chloro-N,N-diphenylacetamide
por: Shao, Shuai, et al.
Publicado: (2009)

Changes of Urinary Cytokines in Non-Diabetic Obese Patients After Laparoscopic Sleeve Gastrectomy
por: Salman, Ahmed, et al.
Publicado: (2021)

Immunogenicity and Safety of an Inactivated SARS-CoV-2 Vaccine: Preclinical Studies
por: Kandeil, Ahmed, et al.
Publicado: (2021)

The Effect of Using Bone Marrow Mesenchymal Stem Cells Versus Platelet Rich Plasma on the Healing of Induced Oral Ulcer in Albino Rats
por: Rashed, Fatma Mohamed, et al.
Publicado: (2019)

Anticonvulsant Potential of Certain New (2E)-2-[1-Aryl-3-(1H-imidazol-1-yl)propylidene]-N-(aryl/H)hydrazinecarboxamides
por: Attia, Mohamed I., et al.
Publicado: (2014)

Investigation of Some Antiviral N-Heterocycles as COVID 19 Drug: Molecular Docking and DFT Calculations
por: Hagar, Mohamed, et al.
Publicado: (2020)

Design and statistical optimisation of emulsomal nanoparticles for improved anti-SARS-CoV-2 activity of N-(5-nitrothiazol-2-yl)-carboxamido candidates: in vitro and in silico studies
por: Al-Karmalawy, Ahmed A., et al.
Publicado: (2023)

The carinogenicity of N-hydroxy-N-2-fluorenyl-acetamide and the matabolism of N-2-fluorenyl-acetamide in Praomis (mastomys) natalensis.
por: Yamamoto, R. S., et al.
Publicado: (1968)

Determinants of having severe acute respiratory syndrome coronavirus 2 neutralizing antibodies in Egypt
por: El Rifay, Amira S., et al.
Publicado: (2021)

Antithyroid Peroxidase Antibodies and Histopathological Outcomes in Egyptian Patients Subjected to Total Thyroidectomy for Non-Malignant Nodular Goiter
por: Rabiee, Ahmed, et al.
Publicado: (2021)

Continuing Threat of Influenza (H5N1) Virus Circulation in Egypt
por: Kayali, Ghazi, et al.
Publicado: (2011)

Quercitrin loaded cyclodextrin based nanosponge as a promising approach for management of lung cancer and COVID-19
por: Abou Taleb, Sally, et al.
Publicado: (2022)

Corrigendum to “Quercitrin loaded cyclodextrin based nanosponge as a promising approach for management of lung cancer and COVID-19” [J. Drug Deliv. Sci. Technol. 77 (2022) 103921]
por: Taleb, Sally Abou, et al.
Publicado: (2023)

N-Hydroxy-N-o-tolylacetamide
por: Li, Yu-Hao, et al.
Publicado: (2008)

Urea–N,N-dimethylacetamide (1/1)
por: Fernandes, Philippe, et al.
Publicado: (2008)

2-Chloro-N-isopropyl-N-phenylacetamide
por: Yuan, Mao-Sen, et al.
Publicado: (2010)

2-Chloro-N-methyl-N-phenylacetamide
por: Zhi, Li-Hua, et al.
Publicado: (2010)

Synthesis, Cytotoxic, and Computational Screening of Some Novel Indole–1,2,4-Triazole-Based S-Alkylated N-Aryl Acetamides
por: Zahoor, Ameer Fawad, et al.
Publicado: (2023)

In Vitro and In Vivo Antiviral Studies of New Heteroannulated 1,2,3-Triazole Glycosides Targeting the Neuraminidase of Influenza A Viruses
por: Kutkat, Omnia, et al.
Publicado: (2022)

Synthesis, Docking Study and β-Adrenoceptor Activity of Some New Oxime Ether Derivatives
por: Ghabbour, Hazem A., et al.
Publicado: (2014)

N-(4-Sulfamoylphenyl)acetamide
por: Asiri, Abdullah M., et al.
Publicado: (2012)

N-(Phenylsulfonyl)acetamide
por: Gowda, B. Thimme, et al.
Publicado: (2010)

2-Chloro-N-phenylacetamide
por: Gowda, B. Thimme, et al.
Publicado: (2008)

N-(4-Isopropoxyphenyl)acetamide
por: Zhang, Min, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_c3iosd2qfn0vd5bhjjl5h70drk