Dual activity inhibition of threonine aspartase 1 by a single bisphosphate ligand

Therapy resistance remains a challenge for the clinics. Here, dual-active chemicals that simultaneously inhibit independent functions in disease-relevant proteins are desired though highly challenging. As a model, we here addressed the unique protease threonine aspartase 1, involved in various cance...

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Detalles Bibliográficos
Autores principales: Höing, Alexander, Struth, Robin, Beuck, Christine, Rafieiolhosseini, Neda, Hoffmann, Daniel, Stauber, Roland H., Bayer, Peter, Niemeyer, Jochen, Knauer, Shirley K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709806/
https://www.ncbi.nlm.nih.gov/pubmed/36545626
http://dx.doi.org/10.1039/d2ra06019a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709806/
https://www.ncbi.nlm.nih.gov/pubmed/36545626
http://dx.doi.org/10.1039/d2ra06019a

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