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A Single Point Mutation Blocks the Entrance of Ligands to the Cannabinoid CB(2) Receptor via the Lipid Bilayer
[Image: see text] Molecular dynamic (MD) simulations have become a common tool to study the pathway of ligand entry to the orthosteric binding site of G protein-coupled receptors. Here, we have combined MD simulations and site-directed mutagenesis to study the binding process of the potent JWH-133 a...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709915/ https://www.ncbi.nlm.nih.gov/pubmed/36302505 http://dx.doi.org/10.1021/acs.jcim.2c00865 |