A Single Point Mutation Blocks the Entrance of Ligands to the Cannabinoid CB(2) Receptor via the Lipid Bilayer

[Image: see text] Molecular dynamic (MD) simulations have become a common tool to study the pathway of ligand entry to the orthosteric binding site of G protein-coupled receptors. Here, we have combined MD simulations and site-directed mutagenesis to study the binding process of the potent JWH-133 a...

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Detalles Bibliográficos
Autores principales: Casajuana-Martin, Nil, Navarro, Gemma, Gonzalez, Angel, Llinas del Torrent, Claudia, Gómez-Autet, Marc, Quintana García, Aleix, Franco, Rafael, Pardo, Leonardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709915/
https://www.ncbi.nlm.nih.gov/pubmed/36302505
http://dx.doi.org/10.1021/acs.jcim.2c00865

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